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Mass spectrometry (MS) is an analytical technique that measures the mass-to-charge ratio of charged particles. It is used for determining masses of particles, for determining the elemental composition of a sample or molecule, and for elucidating the chemical structures of molecules, such as peptides and other chemical compounds. The MS principle consists of ionizing chemical compounds to generate charged molecules or molecule fragments and measurement of their mass-to-charge ratios.

 

Mass spectrometry is an important emerging method for the quantiation of proteins using targeted proteomic workflows.

 

Learn more about Protein Mass Spectrometry from the following resources:

Mass Spectrometry Glossary - by the Cambridge Healthtech Institute
Protein Mass Spectroscopy – by Wikipedia
Introduction to Mass Spectrometry - by Alison Ashcroft (University of Leeds)
Introduction to MS Quantitation and Modes of LC/MS Monitoring – by IonSource

MRM Proteomics – Protein Quantification and Biomarker Discovery by Multiple Reaction Monitoring