Features & Benefits

• Multiple methods for lots of constraint data (crosslinking, surface medication, limited proteolysis, etc.)

• Recent high profile publications for protein structure determination

Applications

• Determine tertiary and quaternary structure for difficult-to-crystalize proteins

• Map binding sites and orientations

Features & Benefits

• Put our expertise to work for you

• Let us help you get the most out of your in-house proteomics facilities

• Attend a workshop or come to our site for one-on-one training. Site visits also available.

Applications

• Establish new proteomics workflows in house or implement a custom solution

• Improve existing protocols and analysis workflows

• Train new team members with best practices

Features & Benefits

• Let us use our expertise to develop, tailor or optimize an experimental protocol for your specific research question or project need

Applications

• Custom solutions for your specific experimental problem

• Solutions can be delivered as a service or may be transferred to the client for use in house (e.g., in kit format)

Features & Benefits

• Robust & easy to use

• Uses SIS peptides for reproducible, high precision quantitation

• Does not depend on antibodies for specificity

• Capable of isoform discrimination

• High-throughput & compatible with automation

• Compatible with equipment already installed in clinical labs

Applications

• Clinical applications

• Development of highly robust clinical tests to be used for improving diagnosis, risk stratification and treatment matching

• Development of assays for monitoring treatment response/resistance, toxicity, disease progression

Features & Benefits

• Higher-order structural characterization – reveals hydrogen bonding patterns and solvent exposure

• Close-to-single-residue resolution

• High sequence-coverage

• Reduced back-exchange

• Isoform-specific analysis

Applications

• Biomarker discovery

• Analyze secondary structure of proteins & antibodies <150 kDa

• Compare biosimilars to originator drugs

• Pinpoint conformational changes, bonding patterns, or binding sites

Features & Benefits

• >80 available UPLC-MRM/MS or UPLC-HRMS based assays for reliable quantitation of ~1000 metabolites and small molecules

• Convenient multiplexed methods to quantify metabolites in a given metabolic pathway or in a compound class manner

• Rigorously tested assays with established performance standards for sensitivity, linearity, reproducibility, reliability and stability

• Isotope-labeled internal standards for precise and accurate quantitation

Applications

• Biomarker screening, verification, and/or validation

• Analysis of key biochemical pathways

• Analysis of sugars, cofactors, phospholipids, bile acids, amino acids, fatty acids, carnitines, nucleotides, nucleosides, nucleobases, vitamins, steroids and phytohormones

• Highly multiplexed metabolite quantitation in a variety of complex biofluids and tissue types

Features & Benefits

• Multiple UPLC-FTMS methods for untargeted metabolic profiling for discovery studies

• Identification and relative quantitation of known and unknown metabolites from one analysis

• Wide dynamic range for high and low abundance metabolites

• High resolution, high mass accuracy instrumentation for confident metabolite IDs and discrimination of closely related species

• Option to combine with MS/MS analysis to support high confidence IDs

• Established Quality Control procedures with SOPs

Applications

• Biomarker discovery

• Ideal for comparative studies: there is an unlimited number of samples that can be compared

• Lipidomic analysis

• Tailor extraction protocols to target different classes of small molecules

• Highly multiplexed metabolite quantitation in a variety of complex biofluids and tissue types

Features & Benefits

• fmoc peptide synthesis

• in-house peptide synthesizer

• High purity products with CZE and AAA quality data

Applications

• Generate custom standards for proteomics analysis (natural abundance, heavy-labeled, or double-labeled isotopes)

Features & Benefits

• Characterize post-translational modifications (PTMs)

• Generate isoform-specific information

Applications

• Global glycosylation profiling

• Determine disulphide bonding patterns

Features & Benefits

• Untargeted proteomics approach for discovery studies

• Identification and relative quantitation of 1000s of peptides in one analysis

• Wide dynamic range for high and low abundance protein

• Detect post translational modifications can be detected

• Enhanced sensitivity with Orbitrap instrumentation

• Established Quality Control procedures with validated SOPs

Applications

• Biomarker discovery

• Ideal for comparative studies: up to 4 or 8 labels can be used for multiplexing experiments

Features & Benefits

• Higher-order structural characterization

• Reveals hydrogen bonding patterns

• No size limitation on the proteins that can be analyzed

Applications

• Biomarker discovery

• Analyze secondary structure of proteins & antibodies <150 kDa

• Compare biosimilars to originator drugs

• Pinpoint conformational changes, bonding patterns, or binding sites

Features & Benefits

• Ultrahigh resolution intact mass measurement

• Protein/peptide sequencing – approaching single-residue resolution

Applications

• Determine exact mass of intact protein with extremely high accuracy

• Determine or confirm primary structure of peptides or proteins

Features & Benefits

• >500 available assays for accurate protein quantitation

• Quality MRM-MS technology you can trust: all assays are highly reproducible, rigorously tested for interferences, and characterized according to CPTAC guidelines

• Highly multiplexed panels for accurate quantitation of 100s of proteins from a single sample

• High purity paired heavy/light peptide standards for precise quantitation of every targeted protein

• Extremely high specificity and discrimination of protein isoforms

• No antibodies required

Applications

• Biomarker screening, verification, and/or validation

• Highly multiplexed protein quantitation in a variety of complex biofluids and tissue types

• Panels include med-low abundance proteins associated with cancer, CVD, and other diseases

Features & Benefits

• Enhanced sensitivity and multiplexing for deeper and more comprehensive protein quantitation

• Quantify up to 300 proteins from a single human plasma sample

• Extremely high specificity and discrimination of protein isoforms

Applications

• Biomarker screening and/or verification

• Highly multiplexed protein quantitation in a variety of complex biofluids and tissue types

• Maximum coverage of proteins in the sample

• Quantify low-abundance proteins without the need for an antibodies

Features & Benefits

• Perform MRM-MS with an added enrichment/immunoprecipitation step to quantify very low abundance proteins

Applications

• Biomarker verification/validation

• Quantify selected low-abundance proteins using antibody-based enrichment, while maintaining extremely high specificity and discrimination of protein isoforms

Features & Benefits

• Characterize 3D protein structures (tertiary & quaternary) for difficult-to-crystalize proteins

• >40 custom crosslinking reagents for generating diverse constraint data

• In-house custom software for rapid and automated data analysis

Applications

• Analyze tertiary or quaternary structure of proteins

• Analyze protein folding or misfolding

• Determine protein complex assembly

• Study protein-protein interactions

• Generate constraint data for 3D structure modeling

Features & Benefits

• Characterize 3D protein structures (tertiary & quaternary)

Applications

• Analyze tertiary or quaternary structure of proteins

• Analyze protein folding or misfolding

• Determine protein complex assembly

• Generate additional constraint data for 3D structure modeling

Features & Benefits

• Characterize 3D protein structures (tertiary & quaternary) for difficult-to-crystalize proteinsa

• >10 custom reagents for surface modification

Applications

• Analyze tertiary or quaternary structure of proteins

• Analyze protein folding or misfolding

• Determine protein complex assembly

• Generate additional constraint data for 3D structure modeling

Features & Benefits

• Visualize the Spatial Distribution of >600 Proteins, Peptides, Drugs & Metabolites

• Custom-developed MALDI matrix and coating techniques increase coverage and sensitivity

• FT-ICR-MS offers ultrahigh resolution for compound discrimination

Applications

• Analyze differential abundance of lipids and proteins across tissue samples

• Map the distribution of a drug in tissue

• Functional studies based on protein/metabolite abundance in different structures, compartments or tissue types.