PeptiQuant™ Onco

10,000+ Proteins Quantified.
10x Less Cost.

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Absolute Quantitation for
Translational & Preclinical Research

The ability to generate proteome-wide quantitative data that is truly comparable across laboratories and studies will entirely transform biomedical/clinical research. The proposed method (SysQuan) for system-wide quantitation of the human proteome will minimize the cost and analysis time of multiplexed and precise absolute protein quantitation using LC-MS and stable isotope labelled (SIL) mouse (mice fed 13Lys6-labelled feed) to generate the internal standards. SysQuan technology based on the labelled mouse proteome relies on the fact that 76% of all human proteins share unique tryptic peptides with mouse, and >132k unique tryptic human peptides (no missed cleavages, 7-25 amino acids, containing one Lys residue) are shared with mouse.

Tissue Specific Analysis

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  • Including:

    Plasma

    Brain: cerebrum, cerebellum and brain stem

    Cecum

    Colon

    Duodenum

    Epididymis

    Heart

    Ileum

    Jejunum

    Kidneys

    Liver

    Lung

    Ovary

    Pancreas

    Prostate

    Seminal vesicles

    Soleus & gastrocnemius muscle

    Spleen

    Testes

    Thymus

    Thyroid

    Inguinal lymph node

    Lymph nodes 

    Adrenal

    Bladder

    Eyes

    Gallbladder

    Skin

    Stomach

    Uterus

    Esophagus

    Femur

    Parotid salivary gland

    Rectum

    Sciatic nerve 

    Spinal cord

    Salivary gland

    Tibia

    Tongue

    Trachea

Applications

SysQuan will transform large-scale health-related research projects by dramatically lowering the cost of large-scale and population-wide testing and screening. To understand disease and to identify earlier markers of disease, cohorts with 1,ooo-10,000s of samples need to be analysed. While this is routine for genomics and also transcriptomics, the more phenotypic readout of the proteome is massively hindered by the high cost and low-throughput of MS technologies and the limitations of aptamer/antibody-based technologies (mainly relative quantitation, absolute quantitation only in a few cases, low specificity, high false positive rate).

With SysQuan this will change, paving the way for low-cost population-wide absolute quantitative proteomics in a standardized fashion. This will undoubtedly lead to the identification of early (or earlier) markers of disease which will improve treatment outcomes. It can also be used to compare responses to different drugs, thus not only helping to prevent disease progression, but also to improve the treatment of diseases.

SYSQUAN DATABASE

Browse the SysQuan species database to check whether your proteins are covered across tissues.

SysQuan™ delivers:

  • True absolute concentrations

  • High inter-study and inter-laboratory reproducibility

  • Robust performance across preclinical and translational models

Key Features

  •       Isotopically labeled internal standards

  •       Multiplexed quantitation      

  •       High sensitivity and specificity

  •       Fully documented, audit-ready workflows

Applications

  •       Biomarker discovery & validation

  •       Drug efficacy and mechanism-of-action studies

  •       Disease model profiling

  •       Translational research and multi-omics integration